National Pest Management Plan for TB seeks feedback
As an independent review of the National Pest Management Plan for TB finds the goal of complete eradication by 2055 is still valide, feedback is being sought on how to finish the job.
It is often overstated that NZ has the best scientists in the world, but in this case it is true, says Pridmore, who is also chair of the Pastoral Greenhouse Gas Research Consortium.
They are trying to solve the problem of methane in pastoral animals and a vaccine is well suited to that, he told the International Federation of Agricultural Journalists Congress in Hamilton this month.
"If you can get a vaccine that works you will deal with every ruminant anywhere in the world."
A vaccine uses the body's antibodies to fight what is in your body. "It is your own body fighting itself, so you don't have to worry about toxicity, you don't have to worry about drugs and other implications," he told the congress.
"If you develop a vaccine you can bring it to the market in less than three to five years."
He says if you develop an inhibitor – a chemical compound that you put into an animal which kills the methanogens which make methane – it might take 10 years to research a number of aspects to bring it to market.
The vaccine, using a small amount of protein from common methanogens in ruminant animals, would prompt the antibodies within the animal's body to attack it. Normally that wouldn't happen because the rumen is big, there's lots going through and there are not enough antibodies.
The antibodies are developed in the saliva of the ruminant animal and the process is stoked by injecting the animal with blood serum because this and saliva are the most likely places antibodies can be produced.
"Once we inject them it starts a cycle; as the animal eats it salivates all the time, those antibodies keep being pumped into the rumen and you've got a machine that keeps going," Pridmore explained. "This keeps producing antibodies; they attack the methanogens and they get washed out the other end."
Pridmore says a paper came out two weeks ago from the New Zealand scientists. They took every kind of ruminant everywhere in the world from the top of mountains to down in the jungles and looked at the antigens in the guts. Everywhere in the world and with every kind of diet, two kinds of methanogens – the bacteria that make the methane – were found in reasonable abundance. He said if you can knock those two out, the vaccine will work
"The other good thing about a vaccine is it seems to last for a long time."
