fbpx
Print this page
Thursday, 19 September 2013 15:24

TB genome work aids tracing

Written by 

WHOLE GENOME sequencing will give researchers a better understanding of bovine TB outbreaks, a paper presented at a recent Society of General Microbiology conference in the UK predicts.

 

Researchers from the University of Glasgow, working in collaboration with the Agri-Food and Biosciences Institute and the Department of Agriculture and Rural Development, Northern Ireland, sequenced the genomes of 147  million samples of the bacteria responsible for bovine TB, mycobacterium bovis (M. bovis).

The samples came from a decade of outbreaks in Northern Ireland. By combining the genomic sequences of the bacteria with information about when and where the samples were isolated, and stock movement data, researchers were able to build a detailed forensic map of the disease’s spread.

The results show that, even over a few kilometres, M. bovis samples from neighbouring farms were more closely genetically related than those geographically distant on farms which had had cattle moved between them.

The finding confirms that, while long distance spread via cattle movements plays a role, local transmission mechanisms appear to drive the spread of the disease, although the researchers are unable to determine what these are at the present time.

“The inclusion of whole genome information in our data will give us unprecedented insight into how bovine TB spreads, and will help us to develop better control methods for the disease,” says one of the paper’s authors, Hannah Trewby.

Crucially, it will help clarify the role UK native species the badger plays in spreading the disease, and which, after many years of lobbying from farming organisations, the UK Government finally, but controversially, agreed to allow a limited cull of, starting this year.

Professor Rowland Kao, the Principle Investigator of the project, says the Northern Ireland results suggest establishment and local persistence of the pathogen in cattle has a distinct spatial signature.

“We believe that explaining this signature is the key to quantifying the role that badgers play…. While we do not yet have sufficient data to be definitive, it is clear that whole genome sequencing of the bacterium will play an important part in solving this puzzle.”

It should also be a relatively inexpensive way to track TB, farm to farm.

“Given the extensive collection of samples already collected from cattle and badgers, we are optimistic that this approach will help accumulating the right scientific evidence over the coming years to tackle this important problem.”

Rural News invited TBfree New Zealand to comment on this work and what benefit there might be in tracing the disease here, but it was unable to respond before this article went to press.

More like this

Helping farmers fight TB

Peter McNab has been involved with TB Free for more than 30 years and was a key driver and supporter of the programme through the times when bovine TB was present in many herds in Otago. After 33 years on the Otago OSPRI Committee he has stepped down. Here is his story.

On track to eradicate TB

When you hear the word epidemiologist these days you might think of the experts who are figuring out how to tackle Covid-19.

TB fight goes on

The total number of TB-infected herds in Hawke’s Bay has risen to 20, following the recent reclassification of a new herd in the Waitara Valley.

Featured

Feds make case for rural bank lending probe

Bankers have been making record profits in the last few years, but those aren’t the only records they’ve been breaking, says Federated Farmers vice president Richard McIntyre.

National

MPI cuts 391 jobs

The Ministry for Primary Industries (MPI) has informed staff it will cut 391 jobs following a consultation period.

Fonterra unveils divestment plan

Fonterra is exploring full or partial divestment options for its global Consumer business, as well as its integrated businesses Fonterra…

Machinery & Products

GPS in control

In a move that will make harvesting operations easier, particularly in odd-shaped paddocks, Kuhn has announced that GPS section control…